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Mutation Information
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Mutation Site
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T7447C |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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LCR |
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Genotype/Subtype
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HPV16 |
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Viral Reference
|
NC_001526.2
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Country
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China |
Literature Information
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PubMed PMID
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30930693
|
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Disease
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Cervical intraepithelial neoplasia;
Cervical carcinoma
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Published Year
|
2019 |
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Journal
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Cancer cell international |
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Title
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Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China. |
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Author
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Zhe X,Xin H,Pan Z,Jin F,Zheng W,Li H,Li D,Cao D,Li Y,Zhang C,Fu S,Shao R,Pan Z |
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Evidence
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Among the results of LCR sequencing, 33 polymorphic sites were found (the Table lists only 29 sites), of which four polymorphic sites (G7191T, nt7432–7433:GC to CGG, G7518A and A7861 deletions) showed 100% mutation in 95 samples. The remaining 29 mutations were mainly T7447C (39/95, 40.1%), followed by T7199C (16/95, 16.8%), C7268T (16/95, 16.8%), A7285C (16/95, 16.8%), T7711G (16/95, 16.8%), A7727C (16/95, 16.8%), G7839A (16/95, 16.8%) and C24T (16/95, 16.8%).
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HPV Mutation Detail Information