HPV Mutation Detail Information

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Mutation Information

Mutation Site	T727G
Mutation Type	Nucleotide level
Gene/Protein/Region Type	E7
Nucleotide_Mutation	Y59D
Genotype/Subtype	HPV52
Viral Reference	X74481
Country	Korea

Literature Information

PubMed PMID	27977741
Disease	Low grade squamous intraepithelial lesion; High grade squamous intraepithelial lesion; Cervical intraepithelial neoplasia; Cervical carcinoma; Squamous-cell carcinoma
Published Year	2016
Journal	PloS one
Title	Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea.
Author	Choi YJ,Ki EY,Zhang C,Ho WC,Lee SJ,Jeong MJ,Chan PK,Park JS
Evidence	Lineage C also harbored lineage-specific variations (Table 3), of which an E6 nonsynonymous mutation (L83V, concurrent mutations of C348G and G350T) and five E7 nonsynonymous mutations, S52D (concurrent mutations of A706G and G707A), Y55D (T727G), H61Y (C733T), D64N (G742A) and L99R (T848G), showed significant associations with the lineage (P < 0.0001).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation