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Mutation Information
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Mutation Site
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T71R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Nef |
Literature Information
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PubMed PMID
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33787846
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Published Year
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2021 |
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Journal
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The Biochemical journal |
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Title
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Synergy and allostery in ligand binding by HIV-1 Nef. |
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Author
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Aldehaiman A,Momin AA,Restouin A,Wang L,Shi X,Aljedani S,Opi S,Lugari A,Shahul Hameed UF,Ponchon L,Morelli X,Huang M,Dumas C,Collette Y,Arold ST |
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Evidence
|
Compared with the LAI isolate, SF2 Nef has a four amino-acid insertion at the N-terminal region and a T71R substitution that enhances binding to Src family SH3 domains (Figure 1B).
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HIV Mutation Detail Information