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Mutation Information
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Mutation Site
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T69D |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
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NRTIs |
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Country
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Spain |
Literature Information
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PubMed PMID
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33037235
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Disease
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HIV infection/AIDS
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Published Year
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2020 |
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Journal
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Scientific reports |
|
Title
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Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997-2017). |
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Author
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Beltrán-Pavez C,Gutiérrez-López M,Rubio-Garrido M,Valadés-Alcaraz A,Prieto L,Ramos JT,Jiménez De Ory S,Navarro M,Díez-Romero C,Pulido F,Valencia E,Holguín Á,Madrid Cohort of HIV-Infected Children integrated in the Pediatric Branch of the Spanish National AIDS Network (CoRISpe). |
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Evidence
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Among pretreated patients, we identified these specific ADR present over 5% of treated patients. Seven out ten prevalent ADR to NRTIs in the study population (M41L, D67N, T69D, K70R, L210W, T215Y and K219Q) were significantly more frequent in the transferred vs. the non-transferred cohort, mainly D67N, M41L and T215Y (41.7% vs. 6.7%, p < 0.0001;38.9% vs. 13.3%, p = 0.0019;30.1% vs. 6.7%, p = 0.0013, respectively).
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HIV Mutation Detail Information