HIV Mutation Detail Information

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Mutation Information

Mutation Site	T66I
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	raltegravir (RAL)

Literature Information

PubMed PMID	18702518
Published Year	2008
Journal	Biochemistry
Title	Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants.
Author	Marinello J,Marchand C,Mott BT,Bain A,Thomas CJ,Pommier Y
Evidence	The aims of the present study were: 1/ to investigate and compare the effects of raltegravir and elvitegravir on the three IN-mediated reactions: 3'-processing (3'-P), strand transfer (ST) and disintegration;2/ to determine the biochemical activities of seven IN mutants (T66I, L74M, E92Q, F121Y, Q148K, S153Y and N155H) previously selected from drug-resistant patients and isolates;3/ to determine the resistance profile for raltegravir and elvitegravir in those IN mutants.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation