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Mutation Information
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Mutation Site
|
T605C |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
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Combined Mutation
|
gp120.T605C+gp120.A501C |
|
Genotype/Subtype
|
A |
Literature Information
|
PubMed PMID
|
32522853
|
|
Published Year
|
2020 |
|
Journal
|
Journal of virology |
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Title
|
Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands. |
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Author
|
Lu M,Ma X,Reichard N,Terry DS,Arthos J,Smith AB 3rd,Sodroski JG,Blanchard SC,Mothes W |
|
Evidence
|
Shedding of gp120, known to severely complicate structural studies, can be prevented by using the uncleaved gp160JR-FL precursor with alterations in the protease cleavage site (R508S/R511S) or by introducing a disulfide bridge between gp120 and gp41 designated “SOS” (A501C/T605C).
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HIV Mutation Detail Information