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HIV Mutation Detail Information

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Mutation Information
Mutation Site T58S
Mutation Type Amino acid level
Gene/Protein/Region Type Gag
Literature Information
PubMed PMID 30327442
Published Year 2018
Journal mBio
Title Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation.
Author Novikova M,Adams LJ,Fontana J,Gres AT,Balasubramaniam M,Winkler DC,Kudchodkar SB,Soheilian F,Sarafianos SG,Steven AC,Freed EO
Evidence To elucidate the mechanism by which the identified CA-NTD mutations corrected the replication defects imposed by the P122A and I124A substitutions, we focused on the four viral revertants—T58S/T107I/P122A, V11I/T58A/P122A, T58A/I124A, and V11I/T58A/I124A—that exhibited the most improved replication kinetics in Jurkat cells (Fig. 7D and ​andE).E).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation