|
Mutation Information
|
Mutation Site
|
T555C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
rt.V142A+s.F134L |
|
Nucleotide_Mutation
|
F134L |
|
Genotype/Subtype
|
A |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
18171343
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Journal of gastroenterology and hepatology |
|
Title
|
Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. |
|
Author
|
Bottecchia M,Ikuta N,Niel C,Araujo NM,O KM,Gomes SA |
|
Evidence
|
The two first substitutions (nt 481 and 555) originated changes within the major hydrophilic region of HBsAg, and were also non-synonymous for the polymerase, causing the rtS117Y and rtV142A amino acid substitutions, respectively
|
|
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HBV Mutation Detail Information