HBV Mutation Detail Information

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Mutation Information

Mutation Site	T484G
Mutation Type	Nucleotide level
Gene/Protein/Region Type	S
Nucleotide_Mutation	I110M
Genotype/Subtype	A
Immune Escape	Y

Literature Information

PubMed PMID	20881037
Published Year	2010
Journal	Journal of virology
Title	Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site.
Author	Ito K,Qin Y,Guarnieri M,Garcia T,Kwei K,Mizokami M,Zhang J,Li J,Wands JR,Tong S
Evidence	In this regard, the I110M, G119E, M133T, and R169P substitutions in the envelope proteins are caused by the T484G, G510A, T552C, and G660C point mutations in the viral genome, respectively (Fig. (Fig.1A),1A), with the T484G mutation further inducing an S466A substitution in the DNA polymerase.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation