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Mutation Information
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Mutation Site
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T47P |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vif |
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Combined Mutation
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vif.K50R+vif.T47P |
Literature Information
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PubMed PMID
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32446377
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Published Year
|
2020 |
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Journal
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Biochemical and biophysical research communications |
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Title
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Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest. |
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Author
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Nagata K,Shindo K,Matsui Y,Shirakawa K,Takaori-Kondo A |
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Evidence
|
We further examined the potency of Vif mutants for cell cycle arrest induction and PPP2R5D degradation in CEM-SS cells. NL4-3 Vif R33K, N48H, and T47P/K50R induced G2 arrest in CEM-SS cells comparably to NL4-3 Vif wild-type, but I31V/R33G did not (Fig. 4D).
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HIV Mutation Detail Information