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Mutation Information
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Mutation Site
|
T47K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
16830379
|
|
Disease
|
Chronic hepatitis B
|
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Published Year
|
2006 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs. |
|
Author
|
Lu HY,Zeng Z,Xu XY,Zhang NL,Yu M,Gong WB |
|
Evidence
|
Six mutations at amino acid residues 40 (N40S) and 47 (T47V, T47K, T47R) coincident with HLA class I-restricted (CTL) epitope[10] were observed in 5 patients, 11 mutations (26.8%) occurred in 6 patients within the major hydrophilic regions of upstream and downstream of the “α” determinant region (amino acid positions 99-169), 6 mutations at 3 amino acid positions (196, 198 and 199) associated with LMV-selected mutation were observed in 5 patients.
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HBV Mutation Detail Information