HIV Mutation Detail Information

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Mutation Information

Mutation Site	T47A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vif
Combined Mutation	vif.N48A+vif.T47A

Literature Information

PubMed PMID	28302150
Published Year	2017
Journal	Retrovirology
Title	Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function.
Author	Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK
Evidence	Vif mutants W5A–Q6A, H27A–H28A, D37A–W38A, T47A–N48A, P49A–K50A, and I51A–S52A exhibited significant defects in their ability to mediate A3G degradation compared to WT Vif (Fig. 2b, c).;Vif mutants W5A-Q6A, H27A-H28A, D37A-W38A, T47A-N48A, P49A-K50A, and I51A-S52A exhibited significant defects in their ability to mediate A3G degradation compared to WT Vif (Fig. 2b, c).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation