HBV Mutation Detail Information

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Mutation Information

Mutation Site	T476N
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Genotype/Subtype	Adw2

Literature Information

PubMed PMID	10385663
Disease	HBV infection
Published Year	1999
Journal	Hepatology (Baltimore, Md.)
Title	Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation.
Author	Tillmann HL,Trautwein C,Bock T,Böker KH,Jäckel E,Glowienka M,Oldhafer K,Bruns I,Gauthier J,Condreay LD,Raab HR,Manns MP
Evidence	These mutations were a G145Rmutation associated with a D144E mutation of the HBsAg corresponding to aW501E mutantof the HBV-DNA polymer-ase in 2 patients (R01, NR22), and a P120T mutation corresponding to a T476N mutation of the HBV-DNA polymerase in 6 (R01, PR11, NR24, PR 16, PR19, NR26), of whom 1(R01) also had the G145R and D144E mutations.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation