|
Mutation Information
|
Mutation Site
|
T45I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Vpu |
Literature Information
|
PubMed PMID
|
31234536
|
|
Published Year
|
2019 |
|
Journal
|
Medical sciences (Basel, Switzerland) |
|
Title
|
In Silico Insights into HIV-1 Vpu-Tetherin Interactions and Its Mutational Counterparts. |
|
Author
|
Sneha P,Shah U,Balaji S |
|
Evidence
|
The single point mutations in tetherin at positions L23Y, L24T, and P40T, and triple mutations at {L22S, F44Y, L37I} and {L23T, L37T, T45I}, while single point mutations in Vpu at positions A19H and W23Y and triplet of mutations at {V10K, A11L, A19T}, {V14T, I18T, I26S}, and {A11T, V14L, A15T} have revealed no polar contacts with minimal hydrophobic interactions between Vpu and tetherin, resulting in reduced binding affinity.
|
|
|
HIV Mutation Detail Information