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Mutation Information
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Mutation Site
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T419A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
|
IFN-beta |
Literature Information
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PubMed PMID
|
31943114
|
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Published Year
|
2020 |
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Journal
|
Nucleic acids research |
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Title
|
Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase. |
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Author
|
Nguyen PDM,Zheng J,Gremminger TJ,Qiu L,Zhang D,Tuske S,Lange MJ,Griffin PR,Arnold E,Chen SJ,Zou X,Heng X,Burke DH |
|
Evidence
|
The singly substituted p51 subunits were co-expressed with wild-type p66 and purified to yield eight enzymatically active mutant RTs (N418A, T419A, P420A, P421A, L422A, V423A, K424A and L425A) (Supplementary Figure S11).
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HIV Mutation Detail Information