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Mutation Information
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Mutation Site
|
T40S |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PreS1 |
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Genotype/Subtype
|
D |
Literature Information
|
PubMed PMID
|
27486882
|
|
Disease
|
Occult HBV infection;
Hepatocellular carcinoma;
Liver cirrhosis
|
|
Published Year
|
2016 |
|
Journal
|
Oncotarget |
|
Title
|
Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study. |
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Author
|
Coppola N,Onorato L,Iodice V,Starace M,Minichini C,Farella N,Liorre G,Filippini P,Sagnelli E,de Stefano G |
|
Evidence
|
The pre-S1, pre-S2 and S region sequences in HCC tissue showed amino acid (AA) substitutions (F19L, P24L, S59F, T131I, Q129H) and deletions (in positions 4,8, 17 and 86) in the S region, AA substitutions (T40S, P124K, L54P, G76A, N222T and I273L) in pre-S1 region and AA substitutions in pre-S2 region (P41H and P66L).
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HBV Mutation Detail Information