|
Mutation Information
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Mutation Site
|
T375N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
L1 |
|
Genotype/Subtype
|
HPV58 |
|
Viral Reference
|
D90400.1
|
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
25793187
|
|
Disease
|
Low grade squamous intraepithelial lesion;
High grade squamous intraepithelial lesion
|
|
Published Year
|
2015 |
|
Journal
|
BioMed research international |
|
Title
|
Prevalence of human papillomavirus variants and genetic diversity in the L1 gene and long control region of HPV16, HPV31, and HPV58 found in North-East Brazil. |
|
Author
|
Gurgel AP,Chagas BS,do Amaral CM,Nascimento KC,Leal LR,Silva Neto Jda C,Cartaxo Muniz MT,de Freitas AC |
|
Evidence
|
The most common are nucleotide changes were A6540G (I335M), C6828A (N422D), A6014C (L150F), G5994A (V144I), A6799G (I412V), G6823A (D420N), and C6689A (T375N); these are either located in the external loop (DE/HI loop) or alpha helix (H2 and H3) regions.
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HPV Mutation Detail Information