HIV Mutation Detail Information

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Mutation Information

Mutation Site	T369I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.T369I+rt.N348I

Literature Information

PubMed PMID	33477685
Published Year	2021
Journal	Viruses
Title	Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction.
Author	Álvarez M,Sapena-Ventura E,Luczkowiak J,Martín-Alonso S,Menéndez-Arias L
Evidence	Nonnucleoside RT inhibitors (NNRTIs) can interfere with the initiation of plus-strand DNA synthesis by enhancing PPT removal, while HIV RT connection subdomain mutations N348I and N348I/T369I mitigate this effect by altering RNase H cleavage specificity.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation