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Mutation Information
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Mutation Site
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T3516C |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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E2 |
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Nucleotide_Mutation
|
T254N |
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Genotype/Subtype
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HPV16 |
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Country
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Romania |
Literature Information
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PubMed PMID
|
25143263
|
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Disease
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Cervical carcinoma;
Squamous-cell carcinoma;
Cervical intraepithelial neoplasia
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Published Year
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2014 |
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Journal
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Archives of virology |
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Title
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Molecular variants of human papilloma virus 16 E2, E4, E5, E6 and E7 genes associated with cervical neoplasia in Romanian patients. |
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Author
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Plesa A,Anton G,Iancu IV,Diaconu CC,Huica I,Stanescu AD,Socolov D,Nistor E,Popa E,Stoian M,Botezatu A |
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Evidence
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In the transactivation domain, the substitutions C2859A (H35Q), G2890T (A46S), C3158A (T135K) and G3181A (A143T) were found, and within the hinge domain, A3361G (N203D), C3376G (P208A), T3386C (I211T), A3395G (H214R), C3409T (P219L), C3437A (A228D), G3448A (E232K), C3515A (T254N), T3516C (T254N), G3459A (Q235-), A3489G (P245-), A3537C (S261) and T3565G (F271V).
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HPV Mutation Detail Information