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Mutation Information
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Mutation Site
|
T350G |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
E6 |
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Genotype/Subtype
|
HPV16 |
|
Country
|
Tunis |
Literature Information
|
PubMed PMID
|
30583341
|
|
Disease
|
High grade squamous intraepithelial lesion;
Low grade squamous intraepithelial lesion;
Cervical carcinoma
|
|
Published Year
|
2018 |
|
Journal
|
Asian Pacific journal of cancer prevention : APJCP |
|
Title
|
Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions |
|
Author
|
Jendoubi-Ferchichi M,Satouri L,Ghoul F,Malek-Mellouli M,Derbel AM,Makni MK,Reziga H,Baba A,Zili M,Segondy M,Khelifa R |
|
Evidence
|
Indeed, within the 392-nt sequence in ORF E6 (nt 228 to 620), HPV16 strains showed a T350G nt change which is specific to the European German lineage A2 [27] and lead to a L83V substitution, whereas in ORF L1, one isolate showed the (G6719A) substitution, only found in the African sub-lineage B1.
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HPV Mutation Detail Information