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Mutation Information
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Mutation Site
|
T310K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E2 |
|
Amino acid_Mutation
|
C3684A |
|
Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
11308254
|
|
Disease
|
Low grade squamous intraepithelial lesion;
High grade squamous intraepithelial lesion
|
|
Published Year
|
2001 |
|
Journal
|
British journal of cancer |
|
Title
|
Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix. |
|
Author
|
Giannoudis A,Duin M,Snijders PJ,Herrington CS |
|
Evidence
|
In the DNA binding domain of E2, the 3684C-A (T310K) variant (Figure 1A, lanes: 1–4) was identified in 13/38 (34%) high-grade SILs and 2/22 (9%) low-grade SILs by RFLP (P = 0.03, Fisher’s exact test).
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HPV Mutation Detail Information