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Mutation Information
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Mutation Site
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T283N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
Literature Information
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PubMed PMID
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18837996
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Published Year
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2008 |
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Journal
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Retrovirology |
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Title
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The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors. |
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Author
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Rossi F,Querido B,Nimmagadda M,Cocklin S,Navas-Martín S,Martín-García J |
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Evidence
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Therefore, we introduced the N283T mutation into an env clone from a brain-derived isolate and into a brain tissue-derived env clone, and the T283N change into a spleen-derived env from the same individual;however, we found that their phenotypes were not affected.
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HIV Mutation Detail Information