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Mutation Information
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Mutation Site
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T2586C |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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E1 |
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Nucleotide_Mutation
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S574S |
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Genotype/Subtype
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HPV16 |
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Viral Reference
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K02718.1
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Country
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China |
Literature Information
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PubMed PMID
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31341418
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Disease
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Cervical carcinoma
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Published Year
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2019 |
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Journal
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International journal of medical sciences |
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Title
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Human Papillomavirus Type 16 E1 Mutations Associated with Cervical Cancer in a Han Chinese Population. |
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Author
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Yao Y,Yan Z,Dai S,Li C,Yang L,Liu S,Zhang X,Shi L,Yao Y |
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Evidence
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Among these mutations, T921C (T19T), A1041G (L59L), C1096G (Q78E), G1163A (G100E), T1200C (A112A), T1366A (C168S), C1426G (Q188E), T1486C (L208L), T1522A (S220T), C1624T (L154L), A1668G (A268A), C1744A (L294M), C2041T (L393L), G2220C (E452D), C2237G (T458S), G2249A (R462K), C2262T (G466G), C2287T (L475L), T2586C (S574S), A2608C (R582R), T2631A (P589P) and G2650A (E596K) were found only in the HPV16 D3 (AA1) sub-lineage; T933A (A23A) and T1014G (D50E) were observed only in the A4 (As) sub-lineage; A2547G (P561P) was found only in the A1-A3 (EUR) sub-lineage; G2160A (R432R) and T2232C(F456F) was found in both the A4 (As) and A1-A3 (EUR) sub-lineages.
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HPV Mutation Detail Information