|
Mutation Information
|
Mutation Site
|
T257A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gp120 |
|
Relevant Drug
|
peptide triazoles (PT) |
Literature Information
|
PubMed PMID
|
23011758
|
|
Published Year
|
2013 |
|
Journal
|
Proteins |
|
Title
|
HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism. |
|
Author
|
Tuzer F,Madani N,Kamanna K,Zentner I,LaLonde J,Holmes A,Upton E,Rajagopal S,McFadden K,Contarino M,Sodroski J,Chaiken I |
|
Evidence
|
Two mutations, D474A and T257A, caused large-scale loss of KR21 binding, as well as losses in both CD4/17b and viral inhibition by KR21.
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HIV Mutation Detail Information