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Mutation Information
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Mutation Site
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T254 N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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E2 |
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Amino acid_Mutation
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T3517C |
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Genotype/Subtype
|
HPV16 |
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Viral Reference
|
HQ644251.1
|
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Immune Escape
|
Y |
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Country
|
China |
Literature Information
|
PubMed PMID
|
30008422
|
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Disease
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Cervical carcinoma
|
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Published Year
|
2018 |
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Journal
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Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
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Title
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The association of human papillomavirus type 16 E2 variations with cervical cancer in a Han Chinese population. |
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Author
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Dai S,Yao Y,Yan Z,Zhou Z,Shi L,Wang X,Sun L,Zhang R,Yao Y |
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Evidence
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Among the sixteen variations, C2860A (H35Q), A3181C (E142D), G3182A (A143T), and T3224A (L157I) were located in the transactivation domain; A3362G (N203D), C3377G (P208A), T3387C (I211T), C3516A (T254N), T3517C (T254N), A3538C (S261S) and T3566G (F271V) were located in the hinge region; and T3664C (Y303Y), T3694A (T313T), T3706C (S317S), G3778T (W341C), and T3805G (V350V) were located in the DNA binding domain.
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HPV Mutation Detail Information