|
Mutation Information
|
Mutation Site
|
T22A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
E1^E4 |
|
Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
15767402
|
|
Published Year
|
2005 |
|
Journal
|
Journal of virology |
|
Title
|
Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes. |
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Author
|
Davy CE,Jackson DJ,Raj K,Peh WL,Southern SA,Das P,Sorathia R,Laskey P,Middleton K,Nakahara T,Wang Q,Masterson PJ,Lambert PF,Cuthill S,Millar JB,Doorbar J |
|
Evidence
|
A mutant 16E1 E4 (T22A, T23A) which does not bind cyclin B1 or alter its intracellular location fails to induce G2 arrest.
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HPV Mutation Detail Information