HIV Mutation Detail Information

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Mutation Information

Mutation Site	T215Y
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	efavirenz (EFV)
Country	Thailand

Literature Information

PubMed PMID	22132100
Disease	HIV infection/AIDS
Published Year	2011
Journal	PloS one
Title	Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis.
Author	Ngo-Giang-Huong N,Jourdain G,Amzal B,Sang-a-gad P,Lertkoonalak R,Eiamsirikit N,Tansuphasawasdikul S,Buranawanitchakorn Y,Yutthakasemsunt N,Mekviwattanawong S,McIntosh K,Lallemant M,Program for HIV Prevention and Treatment (PHPT) study group.
Evidence	Conversely, the use of an efavirenz-based regimen was associated with significantly increased risks of the mutations P225H (PP[OR>1]>99%), V106M (PP[OR>1]>99%), K103N (PP[OR>1]>99%), L100I (PP[OR>1] = 97%), T215Y (PP[OR>1] = 97.5%) and L210W (PP[OR>1]>99%).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation