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Mutation Information
|
Mutation Site
|
T215Y |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
emtricitabine (FTC) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
18271957
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2008 |
|
Journal
|
Retrovirology |
|
Title
|
Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase. |
|
Author
|
Huigen MC,van Ham PM,de Graaf L,Kagan RM,Boucher CA,Nijhuis M |
|
Evidence
|
Multiple studies have identified mutations at (at least) six codons in the reverse transcriptase (RT) enzyme (thymidine analogue associated mutations (TAMs);M41L, D67N, K70R, L210W, T215Y/F and K219Q/E) that can cause a decrease in Zidovudine susceptibility.
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HIV Mutation Detail Information