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Mutation Information
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Mutation Site
|
T215F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
thymidineanalogue (TAMs) |
|
Country
|
sub‐Saharan Africa;South Asia;Southeast Asia;Latin America;Caribbean |
Literature Information
|
PubMed PMID
|
32936523
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Journal of the International AIDS Society |
|
Title
|
HIV-1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates. |
|
Author
|
Rhee SY,Kassaye SG,Barrow G,Sundaramurthi JC,Jordan MR,Shafer RW |
|
Evidence
|
Tenofovir resistance was defined as the presence of any one of the following four sets of mutations: (i) K65R, K70E and Y115F;(ii) the thymidine‐analogue mutations (TAMs) T215Y/F, which in contrast to the remaining TAMs reduce response to tenofovir‐containing regimens [14];(iii) the multidrug resistance mutations T69S_SS and Q151M and (iv) several additional non‐polymorphic DRMs not on the SDRM list including A62V, K65N, T69del and K70G/Q/N/S/T.
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HIV Mutation Detail Information