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Mutation Information
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Mutation Site
|
T215F |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.T215Y+rt.M41L |
|
Relevant Drug
|
3'-azido-3'-deoxythymidine |
Literature Information
|
PubMed PMID
|
32747359
|
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Published Year
|
2020 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Nucleocapsid Protein Precursors NCp9 and NCp15 Suppress ATP-Mediated Rescue of AZT-Terminated Primers by HIV-1 Reverse Transcriptase. |
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Author
|
Árquez MA,Martín-Alonso S,Gorelick RJ,Scott WA,Acosta-Hoyos AJ,Menéndez-Arias L |
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Evidence
|
In HIV-1, development of resistance to AZT (3'-azido-3'-deoxythymidine) is mediated by the acquisition of thymidine analogue resistance mutations (TAMs) (i.e., M41L, D67N, K70R, L210W, T215F/Y, and K219E/Q) in the viral reverse transcriptase (RT).
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HIV Mutation Detail Information