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Mutation Information
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Mutation Site
|
T215D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
|
A1;B;URF |
|
Relevant Drug
|
NRTIs |
|
Country
|
German |
Literature Information
|
PubMed PMID
|
30650082
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
PloS one |
|
Title
|
Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort. |
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Author
|
Machnowska P,Meixenberger K,Schmidt D,Jessen H,Hillenbrand H,Gunsenheimer-Bartmeyer B,Hamouda O,Kücherer C,Bannert N,German HIV-1 Seroconverter Study Group. |
|
Evidence
|
At NRTI position T215, the mean survival time varied with the specific substitution: T215D and T215S persisted for 4.7 (95% CI 4.4-5.1) and 4.2 (95% CI 3.5-5.1) years, respectively, while T215A and T215N persisted only for 1.6 (95% CI 1.1-2.2) and 1.0 (95% CI 1.0-1.0) years, respectively.
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HIV Mutation Detail Information