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Mutation Information
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Mutation Site
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T178G |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
E6 |
|
Nucleotide_Mutation
|
D25E |
|
Genotype/Subtype
|
HPV16 |
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Country
|
China |
Literature Information
|
PubMed PMID
|
25968097
|
|
Disease
|
HPV infection
|
|
Published Year
|
2016 |
|
Journal
|
Gynecologic and obstetric investigation |
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Title
|
Physical Status and Variant Analysis of Human Papillomavirus 16 in Women from Shanghai. |
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Author
|
Guo Y,Hu J,Zhu L,Sun J,Xie L,Kong F,Han L,Li F |
|
Evidence
|
Sequence analysis demonstrated that mutations of T178G (amino acid change D25E) in E6 (16/21), A647G (amino acid change N29S) in E7 (16/21), C3159A (amino acid change T135K) in E2 (7/10), A3978C (amino acid change P219S) in E5 (8/20), and G7521A (synonymous mutation) in the long control region (LCR, 6/20; fig. 3 ) were the most prevalent variants in each gene segment of the HPV16 genome.
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HPV Mutation Detail Information