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Mutation Information
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Mutation Site
|
T178A |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
|
E6 |
|
Nucleotide_Mutation
|
D25Q |
|
Genotype/Subtype
|
HPV16 |
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Viral Reference
|
NC_001526.2
|
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Country
|
China |
Literature Information
|
PubMed PMID
|
30930693
|
|
Disease
|
Cervical intraepithelial neoplasia;
Cervical carcinoma
|
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Published Year
|
2019 |
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Journal
|
Cancer cell international |
|
Title
|
Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China. |
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Author
|
Zhe X,Xin H,Pan Z,Jin F,Zheng W,Li H,Li D,Cao D,Li Y,Zhang C,Fu S,Shao R,Pan Z |
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Evidence
|
Nineteen single nucleotide changes were identified among the sequencing results for E6 and E7, including 14 missense mutations and five synonymous mutations: 11/14 missense mutations were distributed in the E6 gene (C168G, G176A, T178G, T178A, T183G, A275G, A276G, T295G, T350G, C360A and A442C) and 3/14 missense mutations (A645C, A646C, A647G) were located in the E7 gene.
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HPV Mutation Detail Information