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Mutation Information
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Mutation Site
|
T1754G |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
17380283
|
|
Disease
|
Acute hepatitis B
|
|
Published Year
|
2007 |
|
Journal
|
Journal of gastroenterology |
|
Title
|
Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection. |
|
Author
|
Sainokami S,Abe K,Sato A,Endo R,Takikawa Y,Suzuki K,Okamoto H |
|
Evidence
|
In univariate analysis, seronegativity for hepatitis B envelope antigen (HBeAg) and mutations in both the precore (G1896A and/or G1899A) and core promoter (T1753A/C and/or T1754C/G and/or A1762T/G1764A) were associated with FH (odds ratio [OR], 5.60; P=0.0269 and OR, 52.0; P=0.0006; respectively).
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HBV Mutation Detail Information