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Mutation Information
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Mutation Site
|
T1753V |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Genotype/Subtype
|
C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
25281206
|
|
Disease
|
Liver cirrhosis;
Hepatocellular carcinoma
|
|
Published Year
|
2014 |
|
Journal
|
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
|
Title
|
Impacts of human leukocyte antigen DQ genetic polymorphisms and their interactions with hepatitis B virus mutations on the risks of viral persistence, liver cirrhosis, and hepatocellular carcinoma. |
|
Author
|
Ji X,Zhang Q,Li B,Du Y,Yin J,Liu W,Zhang H,Cao G |
|
Evidence
|
The interaction of rs2856718 AG+GG genotype with T1753V, a HCC-risk mutation, significantly reduced LC risk, with an OR of 0.26 (95% CI, 0.09-0.78); whereas the interaction of rs2856718 AG genotype with C1673T, a LC-risk mutation, significantly increased HCC risk, with an OR of 2.80 (95% CI, 1.02-7.66) in genotype C HBV-infected subjects.
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|
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HBV Mutation Detail Information