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Mutation Information
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Mutation Site
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T1753V |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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PreC |
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Country
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Korea |
Literature Information
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PubMed PMID
|
24344773
|
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Disease
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Hepatocellular carcinoma
|
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Published Year
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2014 |
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Journal
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Journal of viral hepatitis |
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Title
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Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma. |
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Author
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Park YM,Jang JW,Yoo SH,Kim SH,Oh IM,Park SJ,Jang YS,Lee SJ |
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Evidence
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Among those with four mutations, T1753V + G1896A, C1653T + G1896A, G1613A + C1653T and A1846T + G1896A accounted for 88.9% (32 of 36) of HCC cases and 57.4% (35 of 61) of non-HCC cases (P = 0.0013). Of these, only the T1753V + G1896A combination was significantly different between the HCC and non-HCC groups (38.9% vs 11.5%, P = 0.0023).
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HBV Mutation Detail Information