|
Mutation Information
|
Mutation Site
|
T1753C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
C Promoter |
|
Combined Mutation
|
c promoter.C1766T+c promoter.G1764A+c promoter.A1762T+c promoter.T1753C |
|
Genotype/Subtype
|
A |
Literature Information
|
PubMed PMID
|
17627632
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2007 |
|
Journal
|
Hepatology research : the official journal of the Japan Society of Hepatology |
|
Title
|
Impact of viral genotypes and naturally occurring mutations on biological properties of hepatitis B virus. |
|
Author
|
Tong S |
|
Evidence
|
Clone 4B harbored T1753C/A1762T/G1764A/C1766T quadruple mutation in the core promoter. To directly test the contribution of core promoter mutations, point mutations found in clone 4B were introduced stepwise into the low replicating clone 2A.
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|
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HBV Mutation Detail Information