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Mutation Information
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Mutation Site
|
T147C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
C |
|
Viral Reference
|
X72702.1;
X02496.1;
Z35716;
M32138.1;
DQ315780.1;
AY945307.1;
X01587.1;
AB033556.1;
D50519.1;
D23680.1;
M38636.1;
AY233290.1;
M57663.2;
AF297621.1;
AY934772.1;
AY233274.1 |
|
Country
|
India |
Literature Information
|
PubMed PMID
|
26201521
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2012 |
|
Journal
|
Hepatology international |
|
Title
|
Naturally occurring core immune-escape and carboxy-terminal mutations\truncations in patients with e antigen negative chronic hepatitis B. |
|
Author
|
Chauhan R,Sarin SK,Kumar M,Bhattacharjee J |
|
Evidence
|
Common mutations detected in CTL region were cS21T 8/118 (6.7%), cF140S/P 6/118 (5%), cT142P 7/118 (5.9%), and cT147C/P 6/118 (5%), whereas in the B-cell region common mutated sites detected were at positions cV74G/A 13/118 (11%), cE77D 14/118 (11.8%), cA80I/T/V 11/118 (9.3%), cD83E 7/118 (5.4%), and cE113D 6/118 (5%). All mutations detected in core T helper, CTL, and B-cell immunodominant region are given in Fig. 2.
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|
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HBV Mutation Detail Information