|
Mutation Information
|
Mutation Site
|
T147C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
C |
|
Amino acid_Mutation
|
A2339T/C2340G |
|
Genotype/Subtype
|
D |
|
Country
|
India |
Literature Information
|
PubMed PMID
|
25333524
|
|
Disease
|
Hepatocellular carcinoma;
Liver cirrhosis
|
|
Published Year
|
2014 |
|
Journal
|
PloS one |
|
Title
|
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma. |
|
Author
|
Datta S,Ghosh A,Dasgupta D,Ghosh A,Roychoudhury S,Roy G,Das S,Das K,Gupta S,Basu K,Basu A,Datta S,Chowdhury A,Banerjee S |
|
Evidence
|
BCP_T1753C, core_T147C, surface_L213I had contributed significantly in the disease progression to HCC (p < 0.05) in HBeAg positive patients whereas precore_T1858C, core_I116L, core_P130Q and preS1_S98T in HBeAg negative patients.
|
|
|
HBV Mutation Detail Information