HTLV1 Mutation Detail Information

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Mutation Information

Mutation Site	T142I
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp46
Country	Brazil

Literature Information

PubMed PMID	23510700
Disease	HTLV-1 associated myelopathy/tropical spastic paraparesis
Published Year	2013
Journal	Virology journal
Title	Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals.
Author	Mota-Miranda AC,Barreto FK,Amarante MF,Batista E,Monteiro-Cunha JP,Farre L,Galvão-Castro B,Alcantara LC
Evidence	According to our results, other less frequent mutations were associated to changes in the physico-chemical profile and potential protein domains: the T142I mutation was associated to the loss of a N-glycosylation site and to a decrease in antigenicity; the F159S mutation presented a more hydrophilic and flexible profile, associated to the insertion of a N-Myristilation site; and the H290D, C289R and F141S mutations were characterized by an increase in hydrophilicity and flexibility, the opposite of the D197N mutation which was associated to a decrease in flexibility (Data not shown).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation