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Mutation Information
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Mutation Site
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T139I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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33126458
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Published Year
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2020 |
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Journal
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Molecules (Basel, Switzerland) |
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Title
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Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential. |
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Author
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Nahar L,Talukdar AD,Nath D,Nath S,Mehan A,Ismail FMD,Sarker SD |
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Evidence
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As T139I reverse transcriptase proved to be resistant to (+)-calanolide A (1), represents a catalytically efficient enzyme, and requires only a single transition point mutation (ACA ATA) in codon 139 could provide some explanation as to why mutant T139I reverse transcriptase virus strains, but not the other strains containing other amino acid changes at this position, predominantly emerge in cell cultures under (+)-calanolide A (1) pressure.
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HIV Mutation Detail Information