|
Mutation Information
|
Mutation Site
|
T1341C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
X Promoter |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
M12906;
X01587 |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
17888035
|
|
Disease
|
Chronic hepatitis B;
Hepatocellular carcinoma
|
|
Published Year
|
2007 |
|
Journal
|
Cancer science |
|
Title
|
Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma. |
|
Author
|
Zhang KY,Imazeki F,Fukai K,Arai M,Kanda T,Mikata R,Yokosuka O |
|
Evidence
|
The number of nucleotide and amino acid substitutions in most regions was higher in the HCC group than in the non-HCC group, and the following substitutions and deletions were found more frequently in the HCC group than in the non-HCC group: G1317A and T1341C/A/G in the X promoter region were detected in 13 and six of the HCC cases, four and none of the non-HCC cases, respectively; and pre-S2 deletion was detected in eight HCC and none of the non-HCC cases.
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|
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HBV Mutation Detail Information