|
Mutation Information
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Mutation Site
|
T130A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Tax |
|
Viral Reference
|
AB038239
|
Literature Information
|
PubMed PMID
|
21552325
|
|
Published Year
|
2011 |
|
Journal
|
PLoS pathogens |
|
Title
|
NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. |
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Author
|
Zhi H,Yang L,Kuo YL,Ho YK,Shih HM,Giam CZ |
|
Evidence
|
By contrast, TaxH43Q and TaxT130A, L131S (M22) are defective in NF-kappaB activation, but are able to trans-activate the HTLV-1 LTR.
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HTLV1 Mutation Detail Information