HBV Mutation Detail Information

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Mutation Information

Mutation Site	T12S
Mutation Type	Amino acid level
Gene/Protein/Region Type	C
Genotype/Subtype	D

Literature Information

PubMed PMID	16197491
Disease	Chronic hepatitis B
Published Year	2005
Journal	Alimentary pharmacology & therapeutics
Title	Clinical reactivation during lamivudine treatment correlates with mutations in the precore/core promoter and polymerase regions of hepatitis B virus in patients with anti-hepatitis B e-positive chronic hepatitis.
Author	Marrone A,Zampino R,Karayannis P,Cirillo G,Cesaro G,Guerrera B,Ricciotti R,del Giudice EM,Utili R,Adinolfi LE,Ruggiero G
Evidence	Amino acid substitutions were observed in the T‐cell epitope at position T12S in five of eight (62%) patients in group A, in one of five (20%) in group B1 and in zero of nine in group B2 (P = 0.009).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation