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Mutation Information
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Mutation Site
|
T126N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
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Genotype/Subtype
|
A |
|
Country
|
Botswana |
Literature Information
|
PubMed PMID
|
30382563
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2019 |
|
Journal
|
Virus genes |
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Title
|
Molecular characterization of hepatitis B virus in blood donors in Botswana. |
|
Author
|
Choga WT,Anderson M,Zumbika E,Moyo S,Mbangiwa T,Phinius BB,Melamu P,Kayembe MK,Kasvosve I,Sebunya TK,Blackard JT,Essex M,Musonda RM,Gaseitsiwe S |
|
Evidence
|
Twelve mutations including diagnostic escape mutations (sY100C, sR122K, sT123A, sC124R, sM133T), vaccine escape mutations (sT126N, sQ129R, sM133L, sF134V) and immunoglobulin therapy failure (sG119R, sG130N, sT140S) were exclusive to isolates obtained from HBV/HIV patients versus n = 4 including sP120L, sG130R, sY134H, and sD144A) (Fig 4) obtained from some isolates from blood donors.
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HBV Mutation Detail Information