|
Mutation Information
|
Mutation Site
|
T126A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.G145R+s.T126A |
|
Amino acid_Mutation
|
A530G |
Literature Information
|
PubMed PMID
|
9303514
|
|
Clinical information
|
Yes
|
|
Disease
|
Fulminant hepatitis B;
Acute hepatitis B
|
|
Published Year
|
1997 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis. |
|
Author
|
Hsu HY,Chang MH,Ni YH,Lin HH,Wang SM,Chen DS |
|
Evidence
|
An S mutant (residue 126, Thr to Ala) initially found in an infant with fulminant hepatitis was replaced by another S mutant (residue 145, Gly to Arg) 4 days later. In a girl withChronic hepatitis B, Ala-126 variant and Arg-145 variant were found at 17 and 25 months of age, respectively.
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|
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HBV Mutation Detail Information