|
Mutation Information
|
Mutation Site
|
T126A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Viral Reference
|
D00329.1
|
|
Immune Escape
|
Y |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
20034521
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2010 |
|
Journal
|
Antiviral research |
|
Title
|
Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients. |
|
Author
|
Liu BM,Li T,Xu J,Li XG,Dong JP,Yan P,Yang JX,Yan L,Gao ZY,Li WP,Sun XW,Wang YH,Jiao XJ,Hou CS,Zhuang H |
|
Evidence
|
Further, due to the overlapping nature of HBV genomes, the most of RT-HBsAg concomitant changes were found concentrated in the A–B interdomain corresponding to the overlapping ‘a’ determinant with a cluster of documented immune-escape mutations, such as sT126A, sI126N, sI/T126S, sT131N and sG145R
|
|
|
HBV Mutation Detail Information