HBV Mutation Detail Information

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Mutation Information

Mutation Site	T123N
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Genotype/Subtype	D
Immune Escape	Y
Country	Italy

Literature Information

PubMed PMID	22086128
Disease	Occult HBV infection
Published Year	2012
Journal	Antiviral research
Title	Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection.
Author	Svicher V,Cento V,Bernassola M,Neumann-Fraune M,Van Hemert F,Chen M,Salpini R,Liu C,Longo R,Visca M,Romano S,Micheli V,Bertoli A,Gori C,Ceccherini-Silberstein F,Sarrecchia C,Andreoni M,Angelico M,Ursitti A,Spanò A,Zhang JM,Verheyen J,Cappiello G,Perno CF
Evidence	By an integrated clinical, structural and mathematical approach, 20 mutations (18 not previously correlated, and two previously associated with HBV immune-escape, T123N and M133T) (Hou et al., 2001, Torresi, 2002) were found to be significantly associated with occult HBV D-genotype infection in vivo, mainly located in the “a-determinant” region.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation