Mutation Information
Mutation Site
|
T118K |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Genotype/Subtype
|
D |
Country
|
Italy |
Literature Information
PubMed PMID
|
25418031
|
Disease
|
HBV infection
|
Published Year
|
2015 |
Journal
|
Hepatology (Baltimore, Md.) |
Title
|
Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression. |
Author
|
Salpini R,Colagrossi L,Bellocchi MC,Surdo M,Becker C,Alteri C,Aragri M,Ricciardi A,Armenia D,Pollicita M,Di Santo F,Carioti L,Louzoun Y,Mastroianni CM,Lichtner M,Paoloni M,Esposito M,D'Amore C,Marrone A,Marignani M,Sarrecchia C,Sarmati L,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V |
Evidence
|
Of the 13 HBsAg mutations found in these patients, 8 of 13 (M103I-L109I-T118K-P120A-Y134H-S143L-D144E-S171F) reside in a major hydrophilic loop (target of neutralizing antibodies [Abs]); some of them are already known to hamper HBsAg recognition by humoral response.
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