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Mutation Information
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Mutation Site
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T116N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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S |
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Genotype/Subtype
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B |
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Country
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US |
Literature Information
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PubMed PMID
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32512942
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Published Year
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2020 |
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Journal
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Cells |
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Title
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N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis. |
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Author
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Dobrica MO,Lazar C,Branza-Nichita N |
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Evidence
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T116N (genotype B) Yes No significant change of HBsAg antigenicity *** TCT123-125NFT (genotype B)TCT123-125NCT (genotypes B and C) Yes Low reactivity against HBsAg AbsImpaired HBsAg secretion *** TSM131-133NSS (genotype B)TSM131-133NST/NYT (genotypes B and C) Yes No significant change of HBsAg antigenicity *** NCT146-148SCT/YCT (genotype C)NCT146-148DCT (genotypes B and C) NoRemoves the conserved N146 glycosylation site No significant change of HBsAg antigenicity-Normal HBsAg secretion *** GTS130-132NTS (genotypes B and C) Yes No significant change of HBsAg antigenicity *** GSS112-114NAT (genotype B)TTS115-117NTS(genotype C) No No significant change of HBsAg antigenicity *** Characterization of HBV N-glycosylation mutations isolated from chronically infected patients. * introduces two N-glycosylation sites, both occupied; ** the isolated clone bears additional mutations within the MHR; *** isolated from a patient with occult hepatitis B infection (OBI); # introduces one N-glycosylation site at 131N; NE, not established.
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HBV Mutation Detail Information